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Original Research Papers

  • He S, Gleason J, Fik-Rymarkiewicz E, DiFiglia A, Bharathan M, Morschauser A, Djuretic I, Xu Y, Krakovsky M, Jankovic V, Buensuceso C, Edinger J, Herzberg U, Hofgartner W, Hariri R. 2017. Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation. Stem Cells 35(6): 1603-1613
  • Zaworski P, von Herrmann KM, Taylor S, Sunshine SS, McCarthy K, Risher N, Newcomb T, Weetall M, Prior TW, Swoboda KJ, Chen KS, Paushkin S. 2016. SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials PLoS ONE 11(3): e0150640.
  • Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT, and the NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators.2016. Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study. Ann Clin Transl Neurol 3(2): 132–145.
  • Steinckwich N, Myers P, Janardhan KS, Flagler ND, King D, Petranka JG, Putney JW. 2015. Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and their infiltration into a murine model of psoriasis-inflamed skin. FASEB Journal. Vol 29(7), 3003-13. (2015)
  • Davis FM, Janoshazi A, Janardhan KS, Steinckwich N, D’Agostin D, Petranka JG, Desai PN, Roberts-Thomson SJ, Bird GS, Tucker DK, Fenton SE, Feske S, Monteith GR, Putney JW. 2015. Essential role of Orai1 calcium channels in lactation. PNAS 112(18):5827-32.
  • Czech C, Tang W, Bugawan T, Mano C, Horn C, Iglesias VA, Fröhner S, Zaworski PG, Paushkin S, Chen K, Kremer T. 2015. Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls. PLoS One 10(10): e0139950.
  • Li J, Geisbush TR, Arnold WD, Rosen GD, Zaworski PG, Rutkove SB. 2014. A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model. PLoS One 9(10): e111428.
  • Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki J. 2014. Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol 12(6): 315–341.
  • Ranguelova K, Rice A, Lardinois O, Triquigneaux M, Steinckwich N, Deteding L, Stravos G, Mason RP. 2013. Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils. Free Radic Biol Med (60): 98-106.
  • Scheer N, Balimane P, Hayward M.D., Buechel S, Kauselmann G, Wolf CR. 2012. Generation and Characterization of a Novel MRP2 Humanized Mouse Line Drug Metab Dispos 40(11):2212-8.
  • Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. 2012. The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol 303(5): C490-8.
  • Kruijf PD, Lim HD, Roumen L, Renjaan VA, Zhao J, Webb ML, Auld DS, Wijkmans JCHM, Zaman GJR, Smit MJ, Graaf CD, Leurs R. 2011. Identification of a Novel Allosteric Binding Site in the CXCR2. Chemokine Recept Mol Pharmacol 80:1108-1118.
  • Steinckwich N, Schenten V, Melchior C, Bréchard S, Tschirhart EJ 2011. An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity. J Immunol 186(4): 2182-91.
  • Schenten V, Melchior C, Steinckwich N, Tschirhart EJ, Bréchard S. 2011. Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. J Leukoc Biol 89(4): 587-96.
  • Forde EA, Dogan RE, Karpus WJ. 2011. CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function. J Neuroimmunol 239(1):17-26.
  • Dogan RE, Elhofy A, Karpus WJ. 2011. CCL22 (MDC) regulates Experimental Autoimmune Encephalomyelitis (EAE) by controlling inflammatory macrophages accumulation and effector function. J Leukoc Biol 89(1): 93-104.
  • Dogan RE, Elhofy A, Karpus WJ. 2008. Production of CCL2 (MCP-1) by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J Immunol 180(11):7376-84.
  • Xu Y, Choi J, Hylander B, Sen A, Evan S, Kraybill W, and Repasky EA. Fever-Range Whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. Int. J. Hyperthermia 23 (6):513-527, 2007
  • Hayward MD, Low MJ. 2007. The contribution of endogenous opioids to operant responding by mice is dependent on gender and background genotype. Neuroscience 144:17-25.
  • Hayward MD, Jones BK, Saparov A, Hain HS, Trillat AC, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. 2007. An Extensive Phenotypic Characterization of the hTNFα Transgenic Mice. BMC Physiol 7:13.
  • Mao SY , Xu Y, Zhang J , Schifferli K, An LL , Leininger J, Kiener PA, Wu H, Coyle AJ, Audoly LP. 2007. Antagonizing HMGB1 inhibits proteinuria in a murine model of lupus-like disease. J Immunol (178):131.24
  • Steinckwich N, Friipat JP, Stasia MJ, Erard M, Boxio R, Tankosic C, Doignon I, Nüsse O. 2007. Potent inhibition of store operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2. J Leukoc Biol 81: 1054-1064.
  • Hayward MD, Schaich-Borg A, Pintar JE, Low MJ. 2006. Differential involvement of endogenous opioids in food reinforcement and sucrose consumption. Pharmacol Biochem Behav 85:601-611.
  • Hayward MD, Low MJ. 2005. Naloxone’s suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin. Brain Res Mol Brain Res 140:91-98.
  • Hayward MD, Hansen ST, Pintar JE, Low MJ. 2004. Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacol Biochem Behav 79:171-181.
  • Boxio R, Bossenmeyer-Pourié C, Steinckwich N, Dournon C and Nüsse O. 2004. Mouse bone marrow contains large numbers of functionally competent neutrophils. J Leukoc Biol 75: 604-611.
  • Appleyard SM, Hayward M, Young JI, Butler AA, Cone RD, Rubinstein M, Low MJ. 2003. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinol 144:1753-1760.
  • Dogan RE. 2003. Prevention of development of autoimmune thyroiditis through cytokine modulation using GM-CSF and Flt3-L. J Interferon Cytokine Res 23(8):467-476.
  • Dogan RE, Chenthamarakshan V, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Absence of IL-4 prevents development of experimental autoimmune Graves’ disease in Balb/C mice. J Immunol 170(4):2195-204.
  • Chenthamarakshan V, Dogan RE, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J Immunol 170:5511-5522.
  • Hayward MD, Pintar JE, Low MJ. 2002. Selective reward deficit in mice lacking beta-endorphin and enkephalin. J Neurosci 22:8251-8258.
  • Al-Zoubi AM., Efimova E, Katithamana S, Martinez O, El-Azami El-Idrissi M, Dogan E Rukiye, Prabhakar BS. 2001. Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on TNF-induced apoptosis and activation of caspase 8 and 3. J Biol Chem 276(50):47202-47211.
  • Hayward MD, Low MJ. 2001. The effect of naloxone on operant behavior for food reinforcers in DBA/2 mice. Brain Res Bull 56:537-543.
  • Mogil JS, Grisel JE, Hayward MD, Bales JR, Rubinstein M, Belknap JK, Low MJ. 2000. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101:709-717.
  • Xu Y, Silver DF, Yanga NP, Oflazoglua E, Hempling RE, Piver MS, Repasky EA. 1999. Characterization of Human Ovarian Carcinomas in a SCID Mouse Model. Gynecol Oncol (72): 161- 170.
  • Harvey SR, Sait SNJ, Xu Y, Bailey JL, Penetrante RM, Markus, G. 1999. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. Amer J Pathol (155): 1115-1120.
  • Burd R, Dziedzic S, Xu Y, Caligiuri MA, Subjeck JR, Repasky EA. 1998. Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration whole body hyperthermia. J Cell Physiol (177): 137-147.
  • Sakakibara T, Xu Y, Bumpers H, Chen FA, Bankert RB, Arredondo M, Edge S, Repasky EA. 1995. Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice. Cancer J Sci Am (2): 291-300.

Reviews and Book Chapters

  • Hayward MD, Buiakova O, Grass D.2011. Minimizing Strain Influences in a Genetically Modified Mouse Phenotyping Platform Ann N Y Acad Sci 1245: 27-30
  • Dogan RE, Karpus WJ. 2004. Chemokines and chemokines receptors in Autoimmune Encephalomyelis as a model for central nervous system inflammatory disease regulation. Frontiers in Bioscience 9:1500-1505.
  • Low MJ, Hayward MD, Appleyard SM, Rubinstein M. 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann N Y Acad Sci 994:192-201. www.annalsnyas.org
  • Xu Y, Edge SB, Hurd TC, Repasky EA, Slocum HK. Implantation and characterization of human breast carcinomas in SCID mice. In: Methods in Mammary Gland Biology and Breast Cancer Research (Margot M. Ip, Bonnie B. Asch, ed), pp 51 – 55. 2000 Kluwer Academic/ Plenum Publishers

Meeting Abstracts

  • Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels, JT Jr. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 296(16): 5956-5974 2018.
  • Stroke, IL, Letourneau, JJ, Miller, TE, Xu, Y, Pechik, I, Savoly, DR, Ma, L, Sturzenbecker, LJ, Sabalski, J, Stein, PD, Webb, ML, Hilbert, DW. Treatment of Clostridium difficile infection with a small molecule inhibitor of toxin UDP-glucose hydrolysis activity. Antimicrob. Agents Chemother. (2018), 62, e00107-18.
  • Letourneau, JJ, Stroke, IL, Hilbert, DW, Sturzenbecker, LJ, Marinelli, BA, Quintero, JG, Sabalski, J, Ma, L, Diller, DJ, Stein, PD, Webb, ML. Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB). Bioorganic & Medicinal Chemistry Letters (2018), 28(4), 756-7.
  • Stroke, IL, Ma, L, Letourneau, JJ, Cole, AG, Li, Y, Marinelli, BA, Malone, J, Paulish-Miller, T, Pechik, I, Quintero, JG, Sabalski, JE, Savoly, DR, Wang, A, Hilbert, DW, Gygax, S, Miller, DK, Stein, P, Webb, M. Miniaturized assays for RhoA inactivation through glucosylation by Clostridium difficile toxin. Society for Laboratory Automation and Screening 4th Annual Conference and Exhibition (Washington, D.C.) 7-11 February, 2015.
  • Stroke, IL, Ma, L, Letourneau, JJ, Cole, AG, Li, Y, Marinelli, BA, Malone, J, Paulish-Miller, T, Pechik, I, Quintero, JG, Sabalski, JE, Savoly, DR, Wang, A, Hilbert, DW, Gygax, S, Miller, DK, Stein, P, Webb, M. Miniaturized assays for RhoA inactivation through glucosylation by Clostridium difficile toxin. Society for Laboratory Automation and Screening 4th Annual Conference and Exhibition (Washington, D.C.) 7-11 February, 2015.
  • Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang C-Y, Gygax SE, Webb M, Nickels JT Jr.Novel Antifungal Drug Discovery Based On Targeting Pathways Regulating The Fungal-Conserved Upc2 Transcription Factor. Antimicrob. Agents Chemother. (2014), 58(1), 258-266.
  • Gallo-Ebert, C; Donigan, M; Stroke, IL.; Swanson, RN.; Manners, MT.; Francisco, J; Toner, G; Gallagher, D; Huang, C-Y; Gygax, SE.; Webb, M; Nickels, JT. Novel Antifungal Drug Discovery Based On Targeting Pathways Regulating The Fungal-Conserved Upc2 Transcription Factor. Antimicrob. Agents Chemother. (2014), 58(1), 258-266.
  • Beasley, JR, Huang, C-Y, Gallo-Ebert, C, Bata, A, Donigan, M, Giordano, C, Kanneganti, N, Malone, J, Sieber-McMaster, E, Nawoschik, S, O’Brien, L, Pham, Q, Severinova, E, Shi, D, Swanson, R, Tovar, K, Xu, X, Zalamea, P, Nickels, J, Stein, P., Webb, MW. Discovery and Optimization of GPBAR1 (TGR5) Agonists. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January 2013.
  • Uveges, A, Severinova, E, Gallagher, D, Kanneganti, N, McQueney, M, Swanson, R. A Robust Ultra-High-Throughput Screening Assay for DEK Binding to DNA. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013
  • Stroke, IL, Sturzenbecker, LJ, Letourneau, JJ, Quintero, JG, Sabalski, Joan E, Marinelli, B, Pechik, I, Diller, D, Paulish-Miller, T, Hilbert, DW., Gygax, S, Stein, P, Webb, M. High throughput screening of combinatorial libraries for inhibitors of Clostridium difficile toxins. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013.
  • Beasley JR, Huang C-Y, Gallo-Ebert C, Bata A, Donigan M, Giordano C, Kanneganti N, Malone J, Sieber-McMaster E, Nawoschik S, O’Brien L, Pham Q, Severinova E, Shi D, Swanson R, Tovar K, Xu X, Zalamea P, Nickels J, Stein P, Webb MW. Discovery and Optimization of GPBAR1 (TGR5) Agonists. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January 2013.
  • Stein, P.Simple and Complex Science and Technology. Rutgers University, November 21, 2013
  • Uveges A, Severinova E, Gallagher D, Kanneganti N, McQueney M, Swanson RA. Robust Ultra-High-Throughput Screening Assay for DEK Binding to DNA. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013.
  • Stroke IL, Sturzenbecker LJ, Letourneau JJ, Quintero JG, Sabalski JE, Marinelli B, Pechik I, Diller D, Paulish-Miller T, Hilbert DW, Gygax S, Stein P, Webb M. High throughput screening of combinatorial libraries for inhibitors of Clostridium difficile toxins. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013.
  • McQueney, MS, Uveges, A, Malone, J, O’Brien, L, Cole, A, Webb, M. An Ultra High Throughput Screen of the Venenum Discovery Library for PARP-1 Inhibitors for The 17th International Inflammation Research Association Conference (Lake George, New York) 9-13 September, 2012.
  • Stroke, IL, Hilbert, DW, Letourneau, JJ, Paulish-Miller, T, Quintero, JG, Sabalski, JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012.
  • Beasley, JR, Malone, J, O’Brien, L, Huang, C, Sieber-McMaster, E, Shi, D, Xu, X, Nawoschik, S, Pham, Q, Webb, M. Discovery of GPBAR1 (TGR5) Agonists from a 1536-well UHTS of the ECLiPS Compound Collection. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012.
  • Beasley JR, Malone J, O’Brien L, Huang C, Sieber-McMaster E, Shi D, Xu X, Nawoschik S, Pham Q, Webb M. Discovery of GPBAR1 (TGR5) Agonists from a 1536-well UHTS of the ECLiPS Compound Collection. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012.
  • Stroke IL, Hilbert DW, Letourneau JJ, Paulish-Miller T, Quintero JG, Sabalski JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012.
  • Webb, M. How to Mine Novel Biology Space with Technology Picks and Shovels. Kean University, March 12, 2012.
  • McQueney MS, Uveges A, Malone J, O’Brien L, Cole A, Webb M. An Ultra High Throughput Screen of the Venenum Discovery Library for PARP-1 Inhibitors for The 17th International Inflammation Research Association Conference (Lake George, New York) 9-13 September, 2012.
  • Webb, M. The Pivitol Role of Vertical Integration in Biotechnology. Rutgers University, November 5, 2012.
  • Hayward, MD, Dogan RE, Buiakova O, Grass DS, Phelan JM, Wissenbach M. Physiological and Behavioral Characterization of C57BL/6NTac and Balb/C Mice 63rd AALAS, Minneaposlis, November 4-8, 2012
  • Swanson, RN, Stroke, IL, Manners, MT, Gallo-Ebert, C, Nickels, J. Engineering Transcription Factors for Use in Ultra-High Throughput DNA Binding Assays. 7th Annual Protein Engineering Summit (Boston, Massachusetts) 9-13 May, 2011.
  • Stroke, IL, Manners, MT, Swanson, RN, Dimitrov, D, Gallo-Ebert, C, Nickels, J. Targeting the Transcription Factor Upc2 for Antifungal Drug Discovery. Society for Biomolecular Sciences Annual Meeting (Orlando, Florida) 16-31 March, 2011.
  • Stroke IL, Manners MT, Swanson RN, Dimitrov D, Gallo-Ebert C, Nickels J. Targeting the Transcription Factor Upc2 for Antifungal Drug Discovery. Society for Biomolecular Sciences Annual Meeting (Orlando, Florida) 16-31 March, 2011
  • Swanson, RN, Stroke, IL, Manners, MT, Gallo-Ebert, C, Nickels, J. Engineering Transcription Factors for Use in Ultra-High Throughput DNA Binding Assays. 7th Annual Protein Engineering Summit (Boston, Massachusetts) 9-13 May, 2011.
  • Hayward, Michael D., Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova, A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning, ENDO 2011 Boston, June 4-7 2011.
  • Huang C, Zhao J, Simhadri S, Webb M, Ohlmeyer M, Zhi L. Discovery of a Novel Series of mGluR5 Antagonists. Gordon Research Conference, Medicinal Chemistry, Colby- Sawyer College, New London, NH, August 7-12, 2011.
  • Michael D. Hayward, Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning. 62nd AALAS, San Diego October 2-6 2011
  • Chen J, Siew H, Hayward M, Raisinghani M, Buiakova O, Parker R Comprehensive Phenotype of Mice with PCSK9-Y119X Null Mutation PCSK9: from Gene to Therapeutics, Nantes France, 11-13 March 2010
  • Buiakova O, Xu Y, Seibler J, Kissel H, Roschmann E, Michalak E, Nacerddine K, van Lohuizen M, Jonkers J, Grass D. New tools to evaluate genetic targets and therapeutic strategies against cancer: in vivo imaging and inducible systems to modify gene function, European Journal of Cancer Supplements, Volume 8, issue 5 (June, 2010), p. 95
  • Hayward MD, Campbell W, Karagrigoriou S, Chen D, C Chu C, Woczniczka A, McBride M, Petralia S, Grass DS Buiakova O. Mouse Models of Human Cholesterol Metabolism for Pre-Clinical Studies of Lipid Homeostasis ENDO 2010 San Diego, 19-22 June 2010
  • Xu Y, Roschmann E, Buiakova O, Grass D. Bioluminescent imaging in evaluation of therapeutic strategies against cancer: Focus on orthotopic xenograft tumor models with spontaneous metastases, European Journal of Cancer Supplements, Volume 8, issue 7 (November, 2010), p. 91
  • Xu Y, RaoY, Tugusheva MV, Grass DS, Buiakova O. Bioluminescence-based Orthotopic Xenograft Tumor Models with Spontaneous Metastases as New Tools to Evaluate Therapeutic Strategies against Cancer, 2009 World Molecular Imaging Congress September 23-26, 2009, Montréal, Canada