Genesis Global Group
Genesis Drug Discovery & Development
GD3

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Genesis Drug Discovery & Development is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.

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Biochemistry & Bioanalytical

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Biochemical Assays

Biochemical assays are used to test the binding affinity or inhibitory activity of the tested drug candidate with the target enzyme or receptor molecule.

GD3 utilizes the PerkinElmer Envision® Multilabel Plate Reader to conduct these assays efficiently. This advanced platform offers high-speed, high-sensitivity measurements across multiple detection modalities, enabling precise assessment of drug-target interactions.

  • Detection Technologies include
    • Fluorescence
    • Fluorescence polarization (FP)
    • Fluorescence resonance energy transfer (FRET)
    • Time-resolved fluorescence (TRF such as DELFIA®)
    • Homogeneous time-resolved fluorescence (HTRF or TR-TRET)
    • Absorbance
    • Ultra-sensitive luminescence
    • AlphaScreen®
  • Assay Types
    • Primary
    • Selectivity
    • Ortholog
Figure 1: A series of compounds are tested in a HTRF assay on the Envision to develop structure-activity relationship in the development of potential drug candidates. Symbols represent duplicates (±range, error).

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