Cell-Based Assays

Empowering Drug Discovery with Precision Cell-Based Assays

Cell-based assays are the cornerstone of modern drug development, toxicology testing, and disease research. At GD³, our team of seasoned scientists is dedicated to crafting tailored cell-based assays that deliver actionable insights. Whether you're evaluating the efficacy of a promising drug candidate or unraveling the complexities of a disease, our precise assays provide the critical data you need.

• Experience the GD³ difference:
  • Customized Solutions: We partner with you to design assays that perfectly align with your research goals.
  • Unparalleled Expertise: Our scientists bring years of experience and a deep understanding of cell biology to every project.
  • Reliable Results: Count on accurate, reproducible data to drive your research forward.

• Types of cell-based assays:
  • ELISA
  • MSD
  • Fluorescent-based assays
  • Luminescence-based assays
  • Bioluminescent assays
  • Western blots
• Applications:
  • Reporter bioassays (e.g. antibody dependent cell cytotoxicity, immune checkpoint)
  • Cell signaling (e.g. target engagement, kinase activity)
  • Cell health (e.g. apoptosis, cytotoxicity, proliferation, viability)
• ADME Assays
  • Permeability assays
  • Metabolism assays
  • Drug-drug interaction assays (CYP450)
  • Toxicity pathway analysis

Figure 1. Assay parallelism: dilution of recombinant and endogenous PAX6 overlap indicating a lack of matrix effects in two cell lines. Symbols represent duplicates (±range, error bars are smaller than symbols).

Reference:

• Phillip G. Zaworski, Rachel Schwartz, et al. Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay, Analytical Biochemistry, Volume 656, 2022, 114876, ISSN 0003-2697, https://doi.org/10.1016/j.ab.2022.114876.

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