Chemistry
ADC Process Research
Conjugation optimization employs a "design of experiments" (DOE)-based approach for rapid and efficient screening of all relevant reaction parameters such as:
- Linker-payload stoichiometry
- Concentration of solubilizing agents
- Reducing agents, oxidizing agents
- pH of reaction medium
- Reaction temperature
- Agitation rate
- Addition rate
- Effect of co-solvents
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