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Genesis Drug Discovery & Development is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.
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Analytical Chemistry Services - In vitro ADME
Analytical chemistry is a valuable tool throughout the drug discovery process and is a critical step in your compound's success. Assessment of the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of compounds in vitro early in the drug discovery process is more efficient and cost effective. This will enable compound optimization for potency and ADME properties simultaneously, and selection of better compound for costly in vivo studies.
Our team of expert chemists has developed a list of in vitro ADME assays to help you advance your program:
- Liver microsome stability
- Hepatocytes stability
- Plasma protein binding
- Plasma stability
- Solubility
- PAMPA permeability
- Whole blood stability
- Simulated gastric fluid
- Intestinal fluid stability
- Urine stability
GD3 utilizes a range of high-end technologies to analyze and characterize the properties of drug candidates and compounds. Our capabilities include:
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