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Genesis Drug Discovery & Development
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Chemistry

ADC Process Research

Conjugation optimization employs a "design of experiments" (DOE)-based approach for rapid and efficient screening of all relevant reaction parameters such as:

  • Linker-payload stoichiometry
  • Concentration of solubilizing agents
  • Reducing agents, oxidizing agents
  • pH of reaction medium
  • Reaction temperature
  • Agitation rate
  • Addition rate
  • Effect of co-solvents