PK/PD Services

GD³ performs preclinical in vivo pharmacokinetic studies as both stand-alone studies and in parallel with pharmacodynamics, efficacy, and toxicity evaluations. The correlation of PK and functional readouts helps elucidate the relationship between PK and PD, understand the mechanism of drug action, and identify PK properties for further improvement and optimal compound design. GD³ scientists can develop and validate your bioanalytical method, measure your therapeutic's plasma concentration, derive PK parameters, and summarize the experiment and data in a comprehensive report. We can also conduct bioavailability experiments and measure drug concentration in tumors and other organs to better understand the overall distribution into the tissues and drug concentration in target organs. We can also develop and validate bioanalytical methods and conduct experiments under either GLP or non-GLP compliant procedures. Species we work with include mice, rats, rabbits, minipigs and dogs.

Discovery in vivo pharmacokinetic services include:

• Dosing and then collection of blood and tissues from animals
• In vivo PK Assessments
  • PK analysis to determine C_max, T_max, t_1/2, AUC
  • Bioavailability
  • Target organ or tumor penetration
• Pharmacology Support
  • Salt form and formulation assessment
  • Dose-exposure determination
  • Exposure in efficacy models
• Biomarker Studies and PK/PD
• Bioanalytical Services
  • GLP or non-GLP method development and validation
  • GLP or non-GLP bioanalysis

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