News

Donthireddy L, Vonteddu P, Murthy T, Kwak T, Eraslan R, Podojil JR, Elhofy A, Boyne MT, Puisis JJ, Veglia F, Singh SS, Dotiwala F, Montaner LJ, Gabrilovich DI. ONP-302 Nanoparticles Inhibit Tumor Growth By Altering Tumor-Associated Macrophages And Cancer-Associated Fibroblasts. J Cancer 28;13(6):1933-1944 (2022)

Zaworski PG, Schwartz R, Burr J, Skutnik D, Mollin A, Kumar B, Ngumah Q, Welch E, Johnson B, Narasimhan J, Weetall M. 2022. Quantitation of Pax-6 protein in ocular impression cytology samples using an electrochemiluminescence immunoassay. Anal Biochem 1;656:114876. Epub 2022 Sep 2.

Maillet E, Skutnik D, Jamison JA, Bailey D, Bacellar-Galdino M, & Garlick D. 2021. Anti-Inflammatory and Protective Effects of Topical Opthlamic (R)-DOI 0.01% in Allergic Conjunctivitis and Recurrent Intermediate Uveitis Disease Models in Rabbits. IOVS June 2021. 62, 232.

Christiano R. R. Alves PhD1, Ren Zhang MPH1, Alec J. Johnstone BS1, Reid Garner BS1, Eric J. Eichelberger BS1, Salomé Da Silva Duarte Lepez BA1, Vivian Yi BS1, Victoria Stevens B.S.1, Rebekah Poxson BA2, Rachel Schwartz BA2, Phillip Zaworski MS2, Kathryn J. Swoboda. 2020. MD1 Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy Muscle and Nerve DOI: 10.1002/mus.26995 2020 In Press

Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. 2020. Cholesterol Pathway Inhibition Induces TGF-? Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell 38(4):567-583. e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24.PMID: 32976774

Makhov P, Sohn JA, Serebriiskii IG, Fazliyeva R, Khazak V, Boumber Y, Uzzo RG, Kolenko VM. 2020. CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma. Br J Cancer Sep 24. doi: 10.1038/s41416-020-01087-x. Online ahead of print.

Tarpinian S, Rowe J, Husanov R, Saha U, Banerjee P, Eraslan R, Jones B, Festin S, Khazak V. Invivotek, Hamilton, NJ. NexusPharma, Philadelphia, PA. Charles River Laboratories Research Models and Services (RMS), Wilmington, MA. Assessment of sensitivity to a PD-1 check point inhibitor and cisplatin in bladder cancer patient-derived xenografts with various levels of PD-L1 expression in HuCD34NCG mice. Society for Immunotherapy of Cancer 35th Anniversary Annual Meeting & Pre-Conference Programs (SITC 2020); November 9-14, 2020; Virtual.

Ramos DM, d'Ydewalle C, Gabbeta V, Dakka A, Klein SK, Norris DA, Matson J, Taylor SJ, Zaworski PG, Prior TW, Snyder PJ, Valdivia D, Hatem CL, Waters I, Gupte N, Swoboda KJ, Rigo F, Bennett CF, Naryshkin N, Paushkin S, Crawford TO, Sumner CJ. 2019. Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. Clin Invest https://doi.org/10.1172/JCI124120. [Epub ahead of print]

Krais J, Clausen E, Khazak V, Astsaturov I, Scott CL, Johnson N. Assessment of PARPi and cisplatin resistance in BRCA1 exon 11 mutant patient-derived xenografts. American Association for Cancer Research (AACR) Special Conference on Advances in Ovarian Cancer Research; September 13-16, 2019; Atlanta, GA.

Gallo-Ebert C, Francisco J, Liu HY, Draper R, Modi K, Hayward MD, Jones BK, Buiakova O, McDonough V, Nickels, JT Jr. Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J Biol Chem 296(16): 5956-5974 2018

Stroke, IL, Letourneau, JJ, Miller, TE, Xu, Y, Pechik, I, Savoly, DR, Ma, L, Sturzenbecker, LJ, Sabalski, J, Stein, PD, Webb, ML, Hilbert, DW. Treatment of Clostridium difficile infection with a small molecule inhibitor of toxin UDP-glucose hydrolysis activity. Antimicrob. Agents Chemother. (2018), 62, e00107-18

Letourneau, JJ, Stroke, IL, Hilbert, DW, Sturzenbecker, LJ, Marinelli, BA, Quintero, JG, Sabalski, J, Ma, L, Diller, DJ, Stein, PD, Webb, ML. Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB). Bioorganic & Medicinal Chemistry Letters (2018), 28(4), 756-7

Strathmann EA, Peters M, Hosseinibarkooie S, Rigo FW, Bennett CF, Zaworski PG, Chen KS, Nothnagel M. 2018. Wirth B. Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice. PLoS One. 2018 Sep 6;13(9):e0203398. doi: 10.1371/journal.pone.0203398. eCollection

Iyer CC, Corlett KM, Massoni-Laporte A, Duque SI, Madabusi N, Tisdale S, McGovern VL, Le TT, Zaworski PG, Arnold WD, Pellizzoni L, Burghes. 2018. Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. AHM.Hum Mol Genet. 2018 Oct 1;27(19):3404-3416. doi: 10.1093/hmg/ddy251

Decker DE, Skutnik D, Burr J, Pattison C, Cooley-Themm C, Linn DM, & Linn CL. 2018. GDF-15 Levels increase in Aqueous Humor Following Hypertonic Saline Injection into the Episcleral Vein in a Rat Claucoma Model. IOVS July 2018. 59, 3504.

He S, Gleason J, Fik-Rymarkiewicz E, DiFiglia A, Bharathan M, Morschauser A, Djuretic I, Xu Y, Krakovsky M, Jankovic V, Buensuceso C, Edinger J, Herzberg U, Hofgartner W, Hariri R. 2017. Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation. Stem Cells 35(6): 1603-1613

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Iannaccone ST, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT. 2017. NeuroNEXT Clinical Trial Network on behalf of the NN101 SMA Biomarker Investigators. Natural history of infantile-onset spinal muscular atrophy. Ann Neurol. 2017 Dec;82(6):883-891. doi: 10.1002/ana.25101. Epub 2017 Dec 8. Free PMC article. Clinical Trial.

Zaworski P, von Herrmann KM, Taylor S, Sunshine SS, McCarthy K, Risher N, Newcomb T, Weetall M, Prior TW, Swoboda KJ, Chen KS, Paushkin S. 2016. SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials PLoS ONE 11(3): e0150640.

Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT, and the NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators. 2016. Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study. Ann Clin Transl Neurol 3(2): 132-145.

Gaponova AV, Nikonova AS, Deneka A, Kopp MC, Kudinov AE, Skobeleva N, Khazak V, Ogawa LS, Cai KQ, Duncan KE, Duncan JS, Egleston BL, Proia DA, Boumber Y, Golemis EA. A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. Clin Cancer Res. 2016 Oct 15;22(20):5120-5129. doi: 10.1158/1078-0432.CCR-15-3068.

Zaworski P, von Herrmann KM, Taylor S, Sunshine SS, McCarthy K, Risher N, et al. 2016. SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials. PLoS ONE 11(3): e0150640. doi:10.1371/journal.pone.0150640

Kolb, SJ, Coffey, CS, Yankey, JW et al. 2016. Baseline results of the NeuroNext spinal muscular atrophy infant biomarker study. Annals of Clinical and Translational Neurology, 21 January 2016;1-14

Arnold WD, Duque S, Iyer CC, Zaworski P, McGovern VL, Taylor SJ, von Herrmann KM, Kobayashi DT, Chen KS, Kolb SJ, Paushkin SV, Burghes AH. 2016. Normalization of Patient-Identified Plasma Biomarkers in SMNΔ7 Mice following Postnatal SMN Restoration. PLoS One. 2016 Dec 1;11(12):e0167077. doi: 10.1371/journal.pone.0167077. eCollection 2016.

Czech C, Tang W, Bugawan T, Mano C, Horn C, Iglesias VA, Fröhner S, Zaworski PG, Paushkin S, Chen K, Kremer T. 2015. Biomarker for Spinal Muscular Atrophy: Expression of SMN in Peripheral Blood of SMA Patients and Healthy Controls. PLoS One 10(10): e0139950.

Iyer, CC, McGovern, VL, Murray, JD, Gombash, SE, Zaworski, PG, Foust, KD, Janssen, PM and Burghes, AH. 2015. Low levels of survival motor neuron protein are sufficient for normal muscle function in the SMNdelta7 mouse model of SMA. Hum Mol Genet 2015;24(21):6160-73

McGovern, VL, Iyer, CC, Arnold, WD, Gombash, SE, Zaworski, PG, Blatnik, AJ, Foust, KD and Burghes, AH. 2015. SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNdelta7 mouse model of SMA. Hum Mol Genet 2015; 24(19):5524-41

Stroke, IL, Ma, L, Letourneau, JJ, Cole, AG, Li, Y, Marinelli, BA, Malone, J, Paulish-Miller, T, Pechik, I, Quintero, JG, Sabalski, JE, Savoly, DR, Wang, A, Hilbert, DW, Gygax, S, Miller, DK, Stein, P, Webb, M. Miniaturized assays for RhoA inactivation through glucosylation by Clostridium difficile toxin. Society for Laboratory Automation and Screening 4th Annual Conference and Exhibition (Washington, D.C.) 7-11 February, 2015

Li J, Geisbush TR, Arnold WD, Rosen GD, Zaworski PG, Rutkove SB. 2014. A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model. PLoS One 9(10): e111428.

Cherry JJ, Kobayashi DT, Lynes MM, Naryshkin NN, Tiziano FD, Zaworski PG, Rubin LL, Jarecki J. 2014. Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol 12(6): 315-341.

Gallo-Ebert C, Donigan M, Stroke IL, Swanson RN, Manners MT, Francisco J, Toner G, Gallagher D, Huang C-Y, Gygax SE, Webb M, Nickels JT Jr. Novel Antifungal Drug Discovery Based On Targeting Pathways Regulating The Fungal-Conserved Upc2 Transcription Factor. Antimicrob. Agents Chemother. (2014), 58(1), 258-266

Beeharry N, Banina E, Hittle J, Skobeleva N, Khazak V, Deacon S, Andrake M, Egleston BL, Peterson JR, Astsaturov I, Yen TJ. 2014. Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell Cycle;13(14):2172-91. doi: 10.4161/cc.29214

Ranguelova K, Rice A, Lardinois O, Triquigneaux M, Steinckwich N, Deteding L, Stravos G, Mason RP. 2013. Sulfite-mediated oxidation of myeloperoxidase to a free radical: immuno-spin trapping detection in human neutrophils. Free Radic Biol Med (60): 98-106

Khazak V, Eyrisch S, Kato J, Tamanoi F, Golemis EA. 2013. A two-hybrid approach to identify inhibitors of the RAS-RAF interaction. Enzymes. 2013;33 Pt A:213-48. doi: 10.1016/B978-0-12-416749-0.00010-5.

Beasley, JR, Huang, C-Y, Gallo-Ebert, C, Bata, A, Donigan, M, Giordano, C, Kanneganti, N, Malone, J, Sieber-McMaster, E, Nawoschik, S, O'Brien, L, Pham, Q, Severinova, E, Shi, D, Swanson, R, Tovar, K, Xu, X, Zalamea, P, Nickels, J, Stein, P., Webb, MW. Discovery and Optimization of GPBAR1 (TGR5) Agonists. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January 2013

Uveges, A, Severinova, E, Gallagher, D, Kanneganti, N, McQueney, M, Swanson, R . A Robust Ultra-High-Throughput Screening Assay for DEK Binding to DNA. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013

Stroke, IL, Sturzenbecker, LJ, Letourneau, JJ, Quintero, JG, Sabalski, Joan E, Marinelli, B, Pechik, I, Diller, D, Paulish-Miller, T, Hilbert, DW., Gygax, S, Stein, P, Webb, M. High throughput screening of combinatorial libraries for inhibitors of Clostridium difficile toxins. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013

Stein, P. Simple and Complex Science and Technology. Rutgers University, November 21, 2013

Scheer N, Balimane P, Hayward M.D., Buechel S, Kauselmann G, Wolf CR. 2012. Generation and Characterization of a Novel MRP2 Humanized Mouse Line Drug Metab Dispos 40(11):2212-8

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. 2012. The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol 303(5): C490-8

Kobayashi DT, Decker D, Zaworski P, Klott K, McGonigal J, Ghazal N, Sly L, Chung B, Vanderlugt J, Chen KS. 2012. Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein. PLoS One. 2012;7(11):e50763

McQueney, MS, Uveges, A, Malone, J, O’Brien, L, Cole, A, Webb, M. An Ultra High Throughput Screen of the Venenum Discovery Library for PARP-1 Inhibitors for The 17th International Inflammation Research Association Conference (Lake George, New York) 9-13 September, 2012

Stroke, IL, Hilbert, DW, Letourneau, JJ, Paulish-Miller, T, Quintero, JG, Sabalski, JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Beasley, JR, Malone, J, O’Brien, L, Huang, C, Sieber-McMaster, E, Shi, D, Xu, X, Nawoschik, S, Pham, Q, Webb, M. Discovery of GPBAR1 (TGR5) Agonists from a 1536-well UHTS of the ECLiPS Compound Collection. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Stroke IL, Hilbert DW, Letourneau JJ, Paulish-Miller T, Quintero JG, Sabalski JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Webb, M. How to Mine Novel Biology Space with Technology Picks and Shovels. Kean University, March 12, 2012

Webb, M. The Pivitol Role of Vertical Integration in Biotechnology. Rutgers University, November 5, 2012

Hayward, MD, Dogan RE, Buiakova O, Grass DS, Phelan JM, Wissenbach M. Physiological and Behavioral Characterization of C57BL/6NTac and Balb/C Mice 63rd AALAS, Minneaposlis, November 4-8, 2012

Kruijf PD, Lim HD, Roumen L, Renjaan VA, Zhao J, Webb ML, Auld DS, Wijkmans JCHM, Zaman GJR, Smit MJ, Graaf CD, Leurs R. 2011. Identification of a Novel Allosteric Binding Site in the CXCR2. Chemokine Recept Mol Pharmacol 80:1108-1118

Steinckwich N, Schenten V, Melchior C, Bréchard S, Tschirhart EJ. 2011. An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and Fc?R-mediated phagosomal oxidative activity. J Immunol 186(4): 2182-91

Schenten V, Melchior C, Steinckwich N, Tschirhart EJ, Bréchard S. 2011. Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9. J Leukoc Biol 89(4): 587-96

Forde EA, Dogan RE, Karpus WJ. 2011. CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function. J Neuroimmunol 239(1):17-26

Dogan RE, Elhofy A, Karpus WJ. 2011. CCL22 (MDC) regulates Experimental Autoimmune Encephalomyelitis (EAE) by controlling inflammatory macrophages accumulation and effector function. J Leukoc Biol 89(1): 93-104

Hayward MD, Buiakova O, Grass D. 2011. Minimizing Strain Influences in a Genetically Modified Mouse Phenotyping Platform Ann N Y Acad Sci 1245: 27-30

Michael D. Hayward, Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning. 62nd AALAS, San Diego October 2-6 2011

Huang C, Zhao J, Simhadri S, Webb M, Ohlmeyer M, Zhi L. Discovery of a Novel Series of mGluR5 Antagonists. Gordon Research Conference, Medicinal Chemistry, Colby- Sawyer College, New London, NH, August 7-12, 2011

Swanson, RN, Stroke, IL, Manners, MT, Gallo-Ebert, C, Nickels, J. Engineering Transcription Factors for Use in Ultra-High Throughput DNA Binding Assays. 7th Annual Protein Engineering Summit (Boston, Massachusetts) 9-13 May, 2011

Stroke, IL, Manners, MT, Swanson, RN, Dimitrov, D, Gallo-Ebert, C, Nickels, J. Targeting the Transcription Factor Upc2 for Antifungal Drug Discovery. Society for Biomolecular Sciences Annual Meeting (Orlando, Florida) 16-31 March, 2011

Hayward, Michael D., Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning, ENDO 2011 Boston, June 4-7 2011

González-Pérez V, Reiner DJ, Alan JK, Mitchell C, Edwards LJ, Khazak V, Der CJ, Cox AD. 2010. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. J Mol Signal;5:2. doi: 10.1186/1750-2187-5-2.

Ho SB, Luu Y, Shekels LL, Batra SK, Kandarian B, Evans DB, Zaworski PG, Wolfe CL, Heinrikson RL. 2010. Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins. Biochim Biophys Acta 1800(7):629-38. Epub 2010 Mar 20.

Chen J, Siew H, Hayward M, Raisinghani M, Buiakova O, Parker R. Comprehensive Phenotype of Mice with PCSK9-Y119X Null Mutation PCSK9: from Gene to Therapeutics, Nantes France, 11-13 March 2010

Buiakova O, Xu Y, Seibler J, Kissel H, Roschmann E, Michalak E, Nacerddine K, van Lohuizen M, Jonkers J, Grass D. New tools to evaluate genetic targets and therapeutic strategies against cancer: in vivo imaging and inducible systems to modify gene function, European Journal of Cancer Supplements, Volume 8, issue 5 (June, 2010), p. 95

Hayward MD, Campbell W, Karagrigoriou S, Chen D, C Chu C, Woczniczka A, McBride M, Petralia S, Grass DS Buiakova O. Mouse Models of Human Cholesterol Metabolism for Pre-Clinical Studies of Lipid Homeostasis ENDO 2010 San Diego, 19-22 June 2010

Xu Y, Roschmann E, Buiakova O, Grass D.. Bioluminescent imaging in evaluation of therapeutic strategies against cancer: Focus on orthotopic xenograft tumor models with spontaneous metastases, European Journal of Cancer Supplements, Volume 8, issue 7 (November, 2010), p. 91

Xu Y, RaoY, Tugusheva MV, Grass DS, Buiakova O. Bioluminescence-based Orthotopic Xenograft Tumor Models with Spontaneous Metastases as New Tools to Evaluate Therapeutic Strategies against Cancer, 2009 World Molecular Imaging Congress September 23-26, 2009, Montréal, Canada

Dogan RE, Elhofy A, Karpus WJ. 2008. Production of CCL2 (MCP-1) by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J Immunol 180(11):7376-84

Campbell PM, Lee KM, Ouellette MM, Kim HJ, Groehler AL, Khazak V, Der CJ. 2008. Ras-driven transformation of human nestin-positive pancreatic epithelial cells. Methods Enzymol;439:451-65. doi: 10.1016/S0076-6879(07)00431-4.

Rothweiler U, Czarna A, Krajewski M, Ciombor J, Kalinski C, Khazak V, Ross G, Skobeleva N, Weber L, Holak TA. Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem. 2008 Jul;3(7):1118-28. doi: 10.1002/cmdc.200800025.

Xu Y, Choi J, Hylander B, Sen A, Evan S, Kraybill W, and Repasky EA. Fever-Range Whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin. Int. J. Hyperthermia 23 (6):513-527, 2007

Hayward MD, Low MJ. 2007. The contribution of endogenous opioids to operant responding by mice is dependent on gender and background genotype. Neuroscience 144:17-25

Hayward MD, Jones BK, Saparov A, Hain HS, Trillat AC, Bunzel MM, Corona A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. 2007. An Extensive Phenotypic Characterization of the hTNF? Transgenic Mice. BMC Physiol 7:13

Mao SY , Xu Y, Zhang J , Schifferli K, An LL , Leininger J, Kiener PA, Wu H, Coyle AJ, Audoly LP. 2007. Antagonizing HMGB1 inhibits proteinuria in a murine model of lupus-like disease. J Immunol (178):131.24

Steinckwich N, Friipat JP, Stasia MJ, Erard M, Boxio R, Tankosic C, Doignon I, Nüsse O. 2007. Potent inhibition of store operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2. J Leukoc Biol 81: 1054-1064

Khazak V, Astsaturov I, Serebriiskii IG, Golemis EA. 2007. Selective Raf inhibition in cancer therapy. Expert Opin Ther Targets;11(12):1587-609. Review. Erratum in: Expert Opin Ther Targets. 2009 Sep;13(9):1135.

Hao H, Muniz-Medina VM, Mehta H, Thomas NE, Khazak V, Der CJ, Shields JM. 2007. Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol Cancer Ther;6(8):2220-9.

Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA. 2007. Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle;6(19):2386-92.

Skobeleva N, Menon S, Weber L, Golemis EA, Khazak V. 2007. In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors. Mol Cancer Ther;6(3):898-906.

Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ. 2007. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res;67(5):2098-106.

Hayward MD, Schaich-Borg A, Pintar JE, Low MJ. 2006. Differential involvement of endogenous opioids in food reinforcement and sucrose consumption. Pharmacol Biochem Behav 85:601-611

Hayward MD, Low MJ. 2005. Naloxone’s suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin. Brain Res Mol Brain Res 140:91-98

Khazak V, Golemis EA, Weber L. 2005. Development of a yeast two-hybrid screen for selection of human Ras-Raf protein interaction inhibitors. Methods Mol Biol. 310:253-71.

Weber L. Chemistry for chemical genomics. Methods Mol Biol. 2005;310:11-24.

Hayward MD, Hansen ST, Pintar JE, Low MJ. 2004. Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacol Biochem Behav 79:171-181

Boxio R, Bossenmeyer-Pourié C, Steinckwich N, Dournon C and Nüsse O. 2004. Mouse bone marrow contains large numbers of functionally competent neutrophils. J Leukoc Biol 75: 604-611

Lu Y, Sakamuri S, Chen QZ, Keng YF, Khazak V, Illgen K, Schabbert S, Weber L, Menon SR. Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3957-62.

Dogan RE, Karpus WJ. 2004. Chemokines and chemokines receptors in Autoimmune Encephalomyelis as a model for central nervous system inflammatory disease regulation. Frontiers in Bioscience 9:1500-1505

Appleyard SM, Hayward M, Young JI, Butler AA, Cone RD, Rubinstein M, Low MJ. 2003. A role for the endogenous opioid beta-endorphin in energy homeostasis. Endocrinol 144:1753-1760

Dogan RE. 2003. Prevention of development of autoimmune thyroiditis through cytokine modulation using GM-CSF and Flt3-L. J Interferon Cytokine Res 23(8):467-476

Dogan RE, Chenthamarakshan V, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Absence of IL-4 prevents development of experimental autoimmune Graves’ disease in Balb/C mice. J Immunol 170(4):2195-204

Chenthamarakshan V, Dogan RE, Maliszewski C, Holterman MJ, Prabhakar BS. 2003. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. J Immunol 170:5511-5522

Low MJ, Hayward MD, Appleyard SM, Rubinstein M. 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann N Y Acad Sci 994:192-201. www.annalsnyas.org

Hayward MD, Pintar JE, Low MJ. 2002. Selective reward deficit in mice lacking beta-endorphin and enkephalin. J Neurosci 22:8251-8258

Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H, Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, Golemis EA, Tamanoi F, Khazak V. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.

Al-Zoubi AM., Efimova E, Katithamana S, Martinez O, El-Azami El-Idrissi M, Dogan E Rukiye, Prabhakar BS. 2001. Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on TNF?-induced apoptosis and activation of caspase 8 and 3. J Biol Chem 276(50):47202-47211

Hayward MD, Low MJ. 2001. The effect of naloxone on operant behavior for food reinforcers in DBA/2 mice. Brain Res Bull 56:537-543

Mogil JS, Grisel JE, Hayward MD, Bales JR, Rubinstein M, Belknap JK, Low MJ. 2000. Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101:709-717

Xu Y, Edge SB, Hurd TC, Repasky EA, Slocum HK. Implantation and characterization of human breast carcinomas in SCID mice. In: Methods in Mammary Gland Biology and Breast Cancer Research (Margot M. Ip, Bonnie B. Asch, ed), pp 51-55. 2000 Kluwer Academic/ Plenum Publishers

Xu Y, Silver DF, Yanga NP, Oflazoglua E, Hempling RE, Piver MS, Repasky EA. 1999. Characterization of Human Ovarian Carcinomas in a SCID Mouse Model. Gynecol Oncol (72): 161- 170

Harvey SR, Sait SNJ, Xu Y, Bailey JL, Penetrante RM, Markus, G. 1999. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. Amer J Pathol (155): 1115-1120

Burd R, Dziedzic S, Xu Y, Caligiuri MA, Subjeck JR, Repasky EA. 1998. Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration whole body hyperthermia. J Cell Physiol (177): 137-147

Sakakibara T, Xu Y, Bumpers H, Chen FA, Bankert RB, Arredondo M, Edge S, Repasky EA. 1995. Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice. Cancer J Sci Am (2): 291-300

Hayward MD, Buiakova O, Grass D. 2011. Minimizing Strain Influences in a Genetically Modified Mouse Phenotyping Platform Ann N Y Acad Sci 1245: 27-30

Dogan RE, Karpus WJ. 2004. Chemokines and chemokines receptors in Autoimmune Encephalomyelis as a model for central nervous system inflammatory disease regulation. Frontiers in Bioscience 9:1500-1505

Low MJ, Hayward MD, Appleyard SM, Rubinstein M. 2003. State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin. Ann N Y Acad Sci 994:192-201. www.annalsnyas.org

Xu Y, Edge SB, Hurd TC, Repasky EA, Slocum HK. Implantation and characterization of human breast carcinomas in SCID mice. In: Methods in Mammary Gland Biology and Breast Cancer Research (Margot M. Ip, Bonnie B. Asch, ed), pp 51-55. 2000 Kluwer Academic/ Plenum Publishers

Tarpinian S, Rowe J, Husanov R, Saha U, Banerjee P, Eraslan R, Jones B, Festin S, Khazak V. Invivotek, Hamilton, NJ. NexusPharma, Philadelphia, PA. Charles River Laboratories Research Models and Services (RMS), Wilmington, MA. Assessment of sensitivity to a PD-1 check point inhibitor and cisplatin in bladder cancer patient-derived xenografts with various levels of PD-L1 expression in HuCD34NCG mice. Society for Immunotherapy of Cancer 35th Anniversary Annual Meeting & Pre-Conference Programs (SITC 2020); November 9-14, 2020; Virtual.

Krais J, Clausen E, Khazak V, Astsaturov I, Scott CL, Johnson N. Assessment of PARPi and cisplatin resistance in BRCA1 exon 11 mutant patient-derived xenografts. American Association for Cancer Research (AACR) Special Conference on Advances in Ovarian Cancer Research; September 13-16, 2019; Atlanta, GA.

Stroke, IL, Ma, L, Letourneau, JJ, Cole, AG, Li, Y, Marinelli, BA, Malone, J, Paulish-Miller, T, Pechik, I, Quintero, JG, Sabalski, JE, Savoly, DR, Wang, A, Hilbert, DW, Gygax, S, Miller, DK, Stein, P, Webb, M. Miniaturized assays for RhoA inactivation through glucosylation by Clostridium difficile toxin. Society for Laboratory Automation and Screening 4th Annual Conference and Exhibition (Washington, D.C.) 7-11 February, 2015

Beasley, JR, Huang, C-Y, Gallo-Ebert, C, Bata, A, Donigan, M, Giordano, C, Kanneganti, N, Malone, J, Sieber-McMaster, E, Nawoschik, S, O'Brien, L, Pham, Q, Severinova, E, Shi, D, Swanson, R, Tovar, K, Xu, X, Zalamea, P, Nickels, J, Stein, P., Webb, MW. Discovery and Optimization of GPBAR1 (TGR5) Agonists. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January 2013

Uveges, A, Severinova, E, Gallagher, D, Kanneganti, N, McQueney, M, Swanson, R . A Robust Ultra-High-Throughput Screening Assay for DEK Binding to DNA. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013

Stroke, IL, Sturzenbecker, LJ, Letourneau, JJ, Quintero, JG, Sabalski, Joan E, Marinelli, B, Pechik, I, Diller, D, Paulish-Miller, T, Hilbert, DW., Gygax, S, Stein, P, Webb, M. High throughput screening of combinatorial libraries for inhibitors of Clostridium difficile toxins. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013

Stein, P. Simple and Complex Science and Technology. Rutgers University, November 21, 2013

McQueney, MS, Uveges, A, Malone, J, O’Brien, L, Cole, A, Webb, M. An Ultra High Throughput Screen of the Venenum Discovery Library for PARP-1 Inhibitors for The 17th International Inflammation Research Association Conference (Lake George, New York) 9-13 September, 2012

Stroke, IL, Hilbert, DW, Letourneau, JJ, Paulish-Miller, T, Quintero, JG, Sabalski, JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Beasley, JR, Malone, J, O’Brien, L, Huang, C, Sieber-McMaster, E, Shi, D, Xu, X, Nawoschik, S, Pham, Q, Webb, M. Discovery of GPBAR1 (TGR5) Agonists from a 1536-well UHTS of the ECLiPS Compound Collection. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Stroke IL, Hilbert DW, Letourneau JJ, Paulish-Miller T, Quintero JG, Sabalski JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening (San Diego, California) 6-8 February, 2012

Webb, M. How to Mine Novel Biology Space with Technology Picks and Shovels. Kean University, March 12, 2012

Webb, M. The Pivitol Role of Vertical Integration in Biotechnology. Rutgers University, November 5, 2012

Hayward, MD, Dogan RE, Buiakova O, Grass DS, Phelan JM, Wissenbach M. Physiological and Behavioral Characterization of C57BL/6NTac and Balb/C Mice 63rd AALAS, Minneaposlis, November 4-8, 2012

Michael D. Hayward, Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning. 62nd AALAS, San Diego October 2-6 2011

Huang C, Zhao J, Simhadri S, Webb M, Ohlmeyer M, Zhi L. Discovery of a Novel Series of mGluR5 Antagonists. Gordon Research Conference, Medicinal Chemistry, Colby- Sawyer College, New London, NH, August 7-12, 2011

Swanson, RN, Stroke, IL, Manners, MT, Gallo-Ebert, C, Nickels, J. Engineering Transcription Factors for Use in Ultra-High Throughput DNA Binding Assays. 7th Annual Protein Engineering Summit (Boston, Massachusetts) 9-13 May, 2011

Stroke, IL, Manners, MT, Swanson, RN, Dimitrov, D, Gallo-Ebert, C, Nickels, J. Targeting the Transcription Factor Upc2 for Antifungal Drug Discovery. Society for Biomolecular Sciences Annual Meeting (Orlando, Florida) 16-31 March, 2011

Hayward, Michael D., Trisha Chu, Steve Karagrigoriou, Duo Chen, William Campbell, Cristina Mottershead, Arthur Wozniczka, Gerald Bothe, Jennifer Phelan, David S. Grass and Olesia Buiakova. A Comparison of Metabolic Characteristics Among C57BL/6NTac, C57BL/6J and C57BL/6JBom Diet Induced Obese Mice With Environmental Conditioning, ENDO 2011 Boston, June 4-7 2011

Chen J, Siew H, Hayward M, Raisinghani M, Buiakova O, Parker R. Comprehensive Phenotype of Mice with PCSK9-Y119X Null Mutation PCSK9: from Gene to Therapeutics, Nantes France, 11-13 March 2010

Buiakova O, Xu Y, Seibler J, Kissel H, Roschmann E, Michalak E, Nacerddine K, van Lohuizen M, Jonkers J, Grass D. New tools to evaluate genetic targets and therapeutic strategies against cancer: in vivo imaging and inducible systems to modify gene function, European Journal of Cancer Supplements, Volume 8, issue 5 (June, 2010), p. 95

Hayward MD, Campbell W, Karagrigoriou S, Chen D, C Chu C, Woczniczka A, McBride M, Petralia S, Grass DS Buiakova O. Mouse Models of Human Cholesterol Metabolism for Pre-Clinical Studies of Lipid Homeostasis ENDO 2010 San Diego, 19-22 June 2010

Xu Y, Roschmann E, Buiakova O, Grass D.. Bioluminescent imaging in evaluation of therapeutic strategies against cancer: Focus on orthotopic xenograft tumor models with spontaneous metastases, European Journal of Cancer Supplements, Volume 8, issue 7 (November, 2010), p. 91

Xu Y, RaoY, Tugusheva MV, Grass DS, Buiakova O. Bioluminescence-based Orthotopic Xenograft Tumor Models with Spontaneous Metastases as New Tools to Evaluate Therapeutic Strategies against Cancer, 2009 World Molecular Imaging Congress September 23-26, 2009, Montréal, Canada