Target Validation
Stage
- Cell based assay development and miniaturization
- Protein Purification and Expression
- In-vitro target validation
- Biochemistry and biomarker development
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HTS
Stage
- 5.6M compound ECLiPS library
- uHTS capabilities
- Compound and data management
- Target deconvolution
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Hit
Stage
- Compound synthesis
- Medicinal, analytical and computational chemistry
- Crystallography and structure-based drug design
- Molecular modelling and protein crystallization
- Expertise in hit-to-lead and lead optimization in broad therapeutic disease areas such as Immuno-oncology, Oncology, Metabolic, Infectious, and CNS diseases.
- Chemists have multi-year experience from both big pharma and biotech companies.
- Five chemistry labs, 22 hoods.
- In house 400 MHz NMR, 3 analytical LC/MS systems, mass-directed purification system
- In house ADME, DMPK and in vivo studies.
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